Dariush Ghasemi

Systematic mediation and interaction analyses in an individual population study help characterize kidney function genetic loci

Published April 10, 2024


CKD is a complex disease affecting >10% of the global population. To identify molecular targets for treatment, genome-wide association study meta-analyses (GWAMAs) of CKD-defining traits have identified hundreds of genetic loci in aggregated populations. Systematic mediation analysis across 70 quantitative traits identified serum magnesium, the activated partial thromboplastin time, and serum urate as partial mediators of the eGFRcrea associations at SHROOM3, SLC34A1, and IGF1R, respectively. Individual population studies can help characterize genetic associations. The interplay between phenotypes at SHROOM3 and SLC34A1 and the role of thyroid function as a genetic effect modifier warrant further investigations.


Our ESR1, Dariush Ghasemi, works on « identification of genetic determinants of kidney function and chronic kidney disease » at Eurac Research, Bolzano/Italy in the group of Cristian Pattaro called Biostatistics & Epidemiology. Dariush manuscript has been submitted to a clinical kidney journal for a peer-review.

Our wish for you, dear Dariush, is success and luck. Finger crossed!